The Effects Of Kratom – Nature’s Miracle Leaf For Pain

Kratom is obtained from the cannabis plant. Due to its many benefits, the kratom demand is increasing. Many studies and research have been conducted to demonstrate the various effects of kratom on the human body. Kratom Users is a highly recommended resource for info on this topic. Below is the discussion of the numerous studies and research:

Kratom and cardiac injury

An investigation was conducted to illustrate the cardiotoxicity of kratom and its analogs. Lu et al. published the study in 2014. In the research, pluripotent stem cells that were extracted from the cardiomyocytes were used. Administration of mitragynine was done. At the end of the study, it was found that the duration action potential was prolonged. Arrhythmia was also induced. Another observation was that mitragynine could cause Torsade de Pointes. The phenomenon results when the mitragynine inhibits rapid delayed rectifier potassium current.

Kratom and kidney injury

Harizal et al. conducted a toxicity study of the standardized methanolic extract of kratom. kratom was administered to rodents. At the end of the study, minimal nephrotoxicity was observed in histopathological results. However, acute severe hepatotoxicity was evident when kratom was administered in very high doses. Mitragyna speciosa is the scientific name of the plant.

Another research was conducted to illustrate the effects of kratom on the kidney. McIntyre et al. described a report of a 24-year old man with a history of depression and alcohol abuse. In the peripheral blood, 0.23mg/l of kratom was detected. In the central blood, its concentration was 0.19mg/l. Together with a negligible amount of ethanol, therapeutic concentrations of mirtazapine, venlafaxine, and diphenhydramine were also found. During the autopsy, Kratom was screened. Pulmonary edema and congestion were evident. There was also urine retention. All these were attributed to kidney injury caused by kratom.

Neurological injury

A research was done in 2010 by Nelsen et al. A case of a 64-year old male was reported. The man experienced a seizure after taking a mixture of kratom and Datura stramonium. He had a history of alcohol and tobacco use. When his urine was screened, traces of cannabinoids, oxycodone, and antidepressants were detected. The seizure most likely was caused by the kratom.

Yusoff et all carried another study in 2016. The researcher concluded that there was impairment of the acquisition, consolidation, and retrieval of memory when mitragynine was administered.

A case was reported by Boyer et al. in 2008. From the report, a patient had stopped consuming hydromorphone. He then switched to kratom as a pain reliever. After taking kratom, the patient reported that he started experiencing a tonic-clonic seizure. Although in animal studies, there is no finding of seizure-like symptoms.

A deficit of cognitive functions can result when mitragynine is administered in rodents. The cognitive deficit was reported in a paper by Suhaimi et al.

Chittrakarn et al. did another research. It was found that skeletal muscle relaxation occurred when mitragynine was administered. Increased concentration of mitragynine and kratom extracts blocked the compound action potential. Therefore, more effects are exhibited at the neuromuscular junction, as compared to the somatic or skeletal muscle. At a concentration of 0.1mg/ml, kratom was found to decrease the contraction of muscles on a phrenic nerve-hemidiaphragm preparation. When mitragynine was administered in high concentrations of 1mg/ml, complete contraction of the relaxed muscle was evident.

Kratom and cellular injury

A study by Saidin et al. was conducted to outline how kratom can cause cellular injury. The cellular toxicity of kratom Korth on a cell of the human was studied. The arrest of the cell cycle was found to occur after the toxicity as the study suggested. The primary cell phases where the arrest took place were G1 and S phase. A high concentration was required to decrease the relative cell number. It was also found that low doses of kratom also stimulates the proliferation of the cells. All these proof that kratom can induce cellular toxicity.

Kratom and Neuromuscular injury

Chittrakarn et al. conducted a study to illustrate how kratom causes neuromuscular injury. In was done in 2010. It was found that mitragynine at a high concentration preferably 2mg/ml produced blockage of the compound nerve action potential. A decrease in the muscle twitch was observed when mitragynine and kratom extract was subjected to the skeletal muscle.

Kratom and Thyroid injury

Sheleg and Collins conducted a study. The study involved a 44-year old man with a positive history of alcohol use. For management of pain, he opted to use kratom for four months. The report suggests that the man gained 60 pounds. He also developed lethargy and myxedematous face. It was found that the patient was suffering from primary hypothyroidism.  It was concluded that the usual response to thyroid-stimulating hormone was reduced in the thyroid gland. This was attributed to the higher doses of the mitragynine in the kratom he was using. Mitragynine could have also suppressed the function of the thyroid gland.

KRATOM: THE BITTER PLANT THAT COULD HELP OPIOID ADDICTS—IF THE DEA DOESN’T BAN IT – you may also want to see this resource.

Kratom and death

Kratom poisoning can cause death as some studies suggest. Karinen et al. did a case report in 2014. It involved a man who had an accidental mitragynine poisoning. The man was found dead and had a diagnosis of mental illness and substance abuse. 0.043mg/l of zopiclone, 5.4mg/l of lamotrigine and 0.36mg/l of citalopram were detected in the toxicological analyses. 1.06mg/l of Mitragynine and 0.15mg/l of 7-hydroxymitragynine were also detected in the sample of patient’s blood. All the levels of zopiclone, lamotrigine, and citalopram were within the required therapeutic ranges. It was, therefore, concluded that the kratom caused the death in this case.

Conclusion

Due to the popularity of kratom, many studies and research are being conducted to outline its effectiveness and adverse side effects. Non-medical use of kratom in western countries is increasing at an alarming rate. Many are using it for self-treatment of pain and opioid withdrawals. From the above-discussed research and studies, it is evident that kratom can pose serious complications, primarily when used in high doses. However, to come up with a standard therapeutic dosage, a lot of research needs to be conducted. As of now, individuals have been advised to use the approved drugs for treatment purposes, instead of kratom.

 

 

 

 

Will the constant flood of non-updating ever abate? Sources close to the site say ‘maybe’

I recently found myself, for reasons I won’t delve in to here, quasi-homeless, sleeping exclusively on a friend’s ant infested couch for nearly two weeks. CBD has held a unique appeal to me for quite some time- maybe it’s because I don’t like the THC in cannabis oils. While I can’t honestly say that the experience of waking up to find several tiny insects building some kind of nest thing in my ear was enlightening in any sort of minimalist, “back to basics” way, beyond the fact that I now unequivically know that I never want that to happen ever, ever again, it did allow a kind of detached perspective on how I’ve been prioritizing my life as of late. If I had to make an ordered list of “Things I Wanted Done” at any given instant during that relatively long, dark period of my life, I think it would’ve gone a little something like this:

1. Find a place to live.
2. Drink myself into oblivion. (while using CBD oil)
3. Figure out what I’m doing with the rest of my life.

999. Eat old, oily rags.
1000. Update the Ultimate Bad Candy Website.

So you can see where my priorities have been. And yet, despite this, I could still be found frequenting our very own forums on an almost daily basis, wasting perfectly good update material on Ben and the disgustingly greasy old man who pretends to be every attractive girl on the Internet, and who also just so happens to be our only regular visitor. But they say that inconsistency is a hallmark of genius, so I guess that reflects well on me and my intellect. And while I totally just made that up, maybe that’s another hallmark of genius: creativity.

maoam_lemon

I’m not sure where I’m going with this update, other than to assure you that I’m almost done with a new review and maybe to garner just a little bit of pity and also to tell you that I think I might be a genius who’s just on CBD oil. So, though I don’t want to spoil any surprises for the upcoming review, I will tell you that we ate whole shrimp, eyeballs and everything, and in the end it was pretty retched. And I’ve got a place to live now, so phew, huh? I bet you were really sweating that out. I did that on purpose, not telling you right away that I’d found a place to live. It created tension and suspense, a hallmark of writing prowess, which is, in turn, a hallmark of my potential genius.

Okay. Bye bye.

4 Corners Cannabis Releases New “Bad Candy” CBD Oil Tincture

4 Corners Cannabis
The company has been established since 2013 and making CBD products made of hemp that are of superior quality. The company considers itself as “growers”, meaning they oversee the beginning to end process of making CBD from growing it to the actual selling. They have total control of all the processes their products go through and they have chosen to farm organically for more superior products, unlike other brands that are merely repackaged. They gently extract the CBD from cannabis using ethanol used in food making to ensure that all the vital active ingredients remain unaffected. And since they also add a few more ingredients to their final product, 4 Corners uphold the integrity and effectivity of the cannabis they sell by choosing only the finest ingredients to be added.

Bad Candy is honored to be a part of this CBD oil.

They do not take any shortcuts. When it comes to quality and how well their CBD lives up to people’s expectations, it is virtually unbeatable. Choose 4 Corners if the quality is at the top of your list in your cannabis. The company acknowledges that the CBD products they make are just about the same grade as that of medical marijuana but all their products are LEGAL in all 50 US states since the THC levels are so law it meets the requirements set forth for hemp-based products by the International Law.

With decades of cannabis experience, you can’t go wrong with 4 Corners. They have logos with an owl and a separate one with a bike in it and they dub it as “OWL POWER” and “BIKE POWER” respectively. You are probably wondering why. The reason for the owl logo is that the products the company sells are made with brain power while the bike logo stands for products made with the human body in mind throughout the production process.

With these logos in mind, you can easily see that this company takes quality at the foremost of everything they do and makes it a point to make products that are safe for the human body and can help people in a lot of ways.

Merry post-Christmas and Happy pre-New Year!

Hello, all. Mark here, hoping that your holiday season was at least bearable. The front page has been a bit quiet lately; my only real excuse is that I’ve been trying very, very hard to get laid for the past month and a half, with no one in particular, and while it’s not really panning out so well as of yet, I’m expecting all of this effort to return dividends in the very near future. Because if it doesn’t, someone is going to get hurt, and I don’t want that to happen.

Meanwhile, the wonderous people who frequent our forums recently organized and executed a Secret Santa gift exchange. Not only did my own Secret Santa not send me a package full of explosives and nails, but I gave as good as I got and the recipient of my own secret gift seemed quite pleased. Overall, it was a pleasant experience to share the holiday spirit with a few of my fellow Internet strangers, and you specifically weren’t invited to join in because you’d probably just fuck it all up. Sorry.

Also, if anyone can clue me in on where all of this new anonymous forum traffic is suddenly coming from as of this morning, please drop me a line. It’s driving me crazy not knowing.

Welcome To Bad Candy

Welcome to the Ultimate Bad Candy Web Site, the virtual crossroads where candy and people barfing up candy meet! Since 1997, Mark and Ben have been saving your ignorant asses by the truckload from the terror of accidentally eating bad candy. And we’ve inadvertantly encouraged about ten times that many people to eat it anyway. So right now I guess we’re in the red as far as people actually saved. Regardless, the cause marches on.

If you’ve never visited our lecherous, hateful little corner of the web before, then let me fill you in on what exactly it is that we do here: we eat bad candy, and then we write about it. We know what you’re thinking: ITS ABOUT DAMN TIME SOMEBODY DID. And you’re right. CBD is life. Often immitated, never duplicated, The Ultimate Bad Candy Web Site is the edgy-yet-retarded food-alternative Internet resource you never realized you’d been looking for your whole life, but have been anyway. If that last sentence made any sense to you, good job, you goddamn crazy .